Yoshimasa Ito Selected Research

Ophthalmic Solutions (Eye Drops)

1/2017	Improvement of Dissolution Rate and Stability in a Pirenoxine Ophthalmic Suspension by the Bead Mill Methods.
3/2015	A nanoparticle formulation of disulfiram prolongs corneal residence time of the drug and reduces intraocular pressure.
1/2015	Decrease in Corneal Damage due to Benzalkonium Chloride by the Addition of Mannitol into Timolol Maleate Eye Drops.
1/2015	Effect of Eye Drops Containing Disulfiram and Low-Substituted Methylcellulose in Reducing Intraocular Pressure in Rabbit Models.
5/2014	A nanoparticle formulation reduces the corneal toxicity of indomethacin eye drops and enhances its corneal permeability.
1/2013	Reduction of enhanced rabbit intraocular pressure by instillation of pyroglutamic acid eye drops.
1/2013	Decrease in corneal damage due to benzalkonium chloride by the addition of sericin into timolol maleate eye drops.
2/2012	Effects of instillation of eyedrops containing disulfiram and hydroxypropyl-β-cyclodextrin inclusion complex on endotoxin-induced uveitis in rats.
1/2012	Pharmacokinetic and pharmacodynamic evaluation of the anti-cataract effect of eye drops containing disulfiram and low-substituted methylcellulose using ICR/f rats as a hereditary cataract model.
1/2012	[In vitro evaluation of corneal damages after instillation of eye drops using rat debrided corneal epithelium: changes of corneal damage due to benzalkonium chloride by addition of thickening agents].

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Yoshimasa Ito Research Topics

Disease

27	Cataract (Cataracts) 01/2017 - 10/2002
10	Arthritis (Polyarthritis) 01/2017 - 10/2007
9	Rheumatoid Arthritis 01/2017 - 01/2009
8	Type 2 Diabetes Mellitus (MODY) 03/2016 - 01/2009
7	Inflammation (Inflammations) 10/2016 - 10/2007
7	Glaucoma 03/2015 - 01/2010
6	Body Weight (Weight, Body) 01/2015 - 01/2009
6	Corneal Injuries 01/2015 - 09/2009
6	Wounds and Injuries (Trauma) 01/2015 - 05/2009
5	Diabetes Mellitus 01/2015 - 01/2009
4	Hyperglycemia 03/2016 - 01/2010
4	Edema (Dropsy) 01/2015 - 10/2007
3	Cerebral Infarction 04/2018 - 05/2008
3	Uveitis 02/2012 - 10/2010
2	Brain Ischemia (Cerebral Ischemia) 01/2018 - 12/2015
2	Ischemic Stroke 01/2018 - 12/2015
2	Adenocarcinoma 02/2016 - 01/2014
2	Adenocarcinoma of Lung 02/2016 - 01/2014
2	Hypercalcemia (Milk Alkali Syndrome) 01/2016 - 01/2015
2	Ocular Hypertension (Glaucoma, Suspect) 01/2013 - 01/2010
2	Optic Nerve Injuries 07/2009 - 05/2008
1	Drug-Related Side Effects and Adverse Reactions 01/2022
1	Polymyalgia Rheumatica (Rhizomelic Pseudopolyarthritis) 01/2022
1	Pain (Aches) 01/2022
1	Vasculitis (Vasculitides) 01/2022
1	Nephritis 09/2021
1	Acute Kidney Injury (Acute Renal Failure) 09/2021
1	IGA Glomerulonephritis (IGA Nephropathy) 12/2018
1	Disease Progression 12/2018

Drug/Important Bio-Agent (IBA)

19	Ophthalmic Solutions (Eye Drops)IBA 01/2017 - 07/2004
12	Disulfiram (Antabuse)FDA Link 01/2015 - 02/2003
9	MagnesiumIBA 01/2017 - 01/2006
9	Glucose (Dextrose)FDA LinkGeneric 01/2015 - 01/2009
8	Messenger RNA (mRNA)IBA 02/2016 - 04/2004
7	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2017 - 11/2007
7	Indomethacin (Indometacin)FDA LinkGeneric 01/2017 - 01/2009
7	SolutionsIBA 03/2015 - 08/2007
6	Pharmaceutical PreparationsIBA 01/2018 - 07/2004
6	SuspensionsIBA 01/2017 - 10/2007
6	Adenosine Triphosphate (ATP)IBA 01/2017 - 04/2004
6	Proteins (Proteins, Gene)FDA Link 02/2016 - 02/2003
6	Adenosine Triphosphatases (ATPase)IBA 01/2016 - 12/2007
6	Interleukin-18 (Interleukin 18)IBA 01/2016 - 11/2007
5	Benzalkonium Compounds (Benzalkonium Chloride)FDA LinkGeneric 01/2015 - 07/2004
4	Cilostazol (Pletal)FDA LinkGeneric 04/2018 - 05/2008
4	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 01/2017 - 12/2007
4	CalciumIBA 01/2016 - 01/2007
4	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2015 - 01/2009
4	Sericins (Sericin)IBA 12/2013 - 05/2009
4	Triglycerides (Triacylglycerol)IBA 01/2013 - 01/2009
4	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 06/2011 - 02/2003
4	2-Hydroxypropyl-beta-cyclodextrinIBA 01/2010 - 07/2004
4	pimagedine (aminoguanidine)IBA 11/2008 - 02/2003
3	EnzymesIBA 12/2018 - 01/2014
3	Amyloid (Amyloid Fibrils)IBA 03/2016 - 01/2014
3	Methylcellulose (BFL)IBA 12/2015 - 01/2012
3	Hypromellose DerivativesIBA 01/2015 - 01/2010
3	HCEIBA 01/2015 - 01/2011
3	Timolol (Blocadren)FDA LinkGeneric 01/2015 - 01/2011
3	Ointments (Pastes)IBA 01/2015 - 01/2014
3	Drinking WaterIBA 01/2014 - 06/2006
3	CholesterolIBA 01/2013 - 01/2009
3	EndotoxinsIBA 02/2012 - 10/2010
2	IpilimumabIBA 01/2022 - 09/2021
2	pembrolizumabIBA 01/2022 - 09/2021
2	Immune Checkpoint InhibitorsIBA 01/2022 - 09/2021
2	NivolumabIBA 01/2022 - 09/2021
2	Therapeutic UsesIBA 01/2018 - 01/2014
2	Biomarkers (Surrogate Marker)IBA 02/2016 - 01/2014
2	Lipase (Acid Lipase)FDA Link 02/2016 - 01/2014
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2016 - 05/2008
2	InterleukinsIBA 01/2016 - 01/2015
2	Antiglaucoma AgentsIBA 01/2015 - 01/2013
2	Sweetening Agents (Sweeteners)IBA 01/2015 - 01/2013
2	DNA (Deoxyribonucleic Acid)IBA 01/2014 - 12/2006
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2014 - 01/2011
2	Insulin (Novolin)FDA Link 01/2013 - 01/2009
2	InterferonsIBA 01/2013 - 06/2011
2	CyclodextrinsIBA 02/2012 - 07/2004
2	Travoprost (Travatan)FDA Link 01/2011 - 01/2010
2	Latanoprost (Xalatan)FDA Link 01/2011 - 01/2010
2	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2010 - 05/2008
2	AntioxidantsIBA 01/2009 - 02/2003
2	Lipid PeroxidesIBA 05/2008 - 05/2008
2	Ditiocarb (Sodium Diethyldithiocarbamate)FDA Link 10/2004 - 02/2003
2	Selenious Acid (Selenite)IBA 07/2004 - 02/2003
1	atezolizumabIBA 09/2021
1	avelumabIBA 09/2021
1	durvalumabIBA 09/2021
1	1- (5- (2- fluorophenyl)- 1- (pyridin- 3- ylsulfonyl)- 1H- pyrrol- 3- yl)- N- methylmethanamineIBA 09/2021
1	Omeprazole (Prilosec)FDA LinkGeneric 09/2021
1	Proton Pump InhibitorsIBA 09/2021
1	Esomeprazole (Nexium)FDA Link 09/2021
1	Lansoprazole (Prevacid)FDA LinkGeneric 09/2021
1	Rabeprazole (Aciphex)FDA Link 09/2021
1	Immunoglobulin A (IgA)IBA 12/2018
1	TabletsIBA 01/2018

Therapy/Procedure

15	Lenses 03/2016 - 02/2003
12	Therapeutics 12/2016 - 10/2007
6	Oral Administration 01/2018 - 10/2007